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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract:

Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobinfor reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 250-257 doi: 10.15302/J-FASE-2014031

Abstract: Foot-and-mouth-disease virus (FMDV) replicates in epithelial cells.The restriction of FMDV RNA to the basal cell layer of epithelia suggests a possible link between FMDVreplication and the cell status.paper describes studies in which FMDV infection was investigated in cells that were held at various celldivision phases using cell cycle inhibitors.

Keywords： foot-and-mouth disease virus     cell cycle     replication    

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Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract:

Liver transplantation is the only life-saving procedure for patients with end-stage liver disease.These issues have prompted the search for new alternative therapies for irreversible liver disease.Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,repopulation of the liver and improved survival rates in experimental models of liver disease.5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratoma

Keywords： stem cell     liver disease     regenerative medicine    

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Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 316-327 doi: 10.1007/s11684-013-0269-z

Abstract: infectious processes such as coccidioidomycosis, Pneumocystis jiroveci pneumonia, and hydatid diseasewith cystic lesions can be seen in pulmonary lymphangioleiomyomatosis, pulmonary Langerhans’ celllymphoid interstitial pneumonia, Birt-Hogg-Dubé syndrome, amyloidosis, light chain deposition diseasehoneycomb lung associated with advanced fibrosis, and several other rare causes including metastatic diseaseCorrelating the tempo of the disease process and clinical context with chest imaging findings serve as

Keywords： cyst     lung disease     interstitial lung disease     lymphangioleiomyomatosis     Langerhans’ cell histiocytosis     Birt-Hogg-Dubé    

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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 91-100 doi: 10.1007/s11684-020-0778-5

Abstract: Congenital heart disease (CHD) is the most common birth defect worldwide.these results suggest that lncRNA SAP30-2:1 may be involved in heart development through affecting cell

Keywords： congenital heart disease     Gene Expression Omnibus     lncRNA SAP30-2:1     cell proliferation     RNA immunoprecipitation    

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patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directeddonor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual diseaseTwo-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell

Keywords： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell

Meng Lv, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 45-56 doi: 10.1007/s11684-017-0595-7

Abstract: Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) haveregimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease

Keywords： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneichematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- )high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cellHigh-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University InstituteThe probability of disease-free and overall survival 2 years after immunotherapy were 76.4% and 78.6%

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 395-405 doi: 10.1007/s11684-012-0231-5

Abstract:

Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during theirsurgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuse lung disease

Keywords： lymphangioleiomyomatosis     lymphangiomyomatosis     multicystic lung disease     diffuse cystic lung disease     transbronchialbiopsy     perivascular epithelioid cell tumor (PEComa)     HMB-45    

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Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 667-679 doi: 10.1007/s11684-019-0702-z

Abstract: Chronic graft-versus-host disease (cGVHD) is a major complication following unmanipulated haploidenticalhematopoietic stem cell transplantation (haplo-HSCT).

Keywords： acute graft-versus-host disease     chronic graft-versus-host disease     National Institutes of Health consensus    

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White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 741-746 doi: 10.1007/s11684-017-0579-7

Abstract: Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD).The relationship between HUA and white blood cell (WBC) count remains unknown.

Keywords： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

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Cell Therapy: A New Era of Disease Intervention

Ling Lu,Zhigang Tian,Xuehao Wang

Engineering 2019, Volume 5, Issue 1,   Pages 3-4 doi: 10.1016/j.eng.2019.01.004

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and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host disease

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: However, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).Syngeneic hematopoietic stem cell transplantation (HSCT) mice served as controls.immunohistochemistry the present study demonstrated that there was strong PAR-1, 2 immunoreactivity in the epithelial celland vascular endothelial cell of target organs of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-HostDisease Review

Bruce R. Blazar

Engineering 2019, Volume 5, Issue 1,   Pages 98-105 doi: 10.1016/j.eng.2018.11.016

Abstract:

The most common approaches to prevent and treat graft-versus-host disease (GVHD) are intended to depletecapable of mediating or supporting alloresponses; however, this renders the recipients functionally T cellAs our knowledge of immune system homeostasis has increased, cell populations with immune regulatoryAlthough such cell populations are typically present in low frequencies, methods to isolate and expandproof of concept of GVHD models, along with GVHD outcomes that focus exclusively on immune regulatory cell

Keywords： Graft-versus-host disease (GVHD)     Immune regulatory cells     Cell therapy    

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Disease Risk Comorbidity Index for Patients Receiving Haploidentical Allogeneic Hematopoietic Transplantation Article

Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang

Engineering 2021, Volume 7, Issue 2,   Pages 162-169 doi: 10.1016/j.eng.2020.12.005

Abstract:

We aimed to develop a disease risk comorbidity index (DRCI) based on disease risk index (DRI) andHematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) in patients receiving haploidenticalhematopoietic stem cell transplantation (haplo-HSCT).We identified the prognostic factors of disease-free survival (DFS) in a training subset (nHaplo-DRCI can also predict DFS in disease-specific subgroups, particularly in acute leukemia patients

Keywords： Disease risk index     Disease risk comorbidity index     Hematopoietic cell transplantation     comorbidity index     Hematopoietic stem cell transplantation     Haploidentical    

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Title Author Date Type Operation

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Journal Article

Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Journal Article

Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

Journal Article

patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directeddonor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell

Meng Lv, Yingjun Chang, Xiaojun Huang

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneichematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

Riffat Meraj, Kathryn A. Wikenheiser-Brokamp, Lisa R. Young, Sue Byrnes, Francis X. McCormack

Journal Article

Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Journal Article

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Journal Article

Cell Therapy: A New Era of Disease Intervention

Ling Lu,Zhigang Tian,Xuehao Wang

Journal Article

and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host disease

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-HostDisease

Bruce R. Blazar

Journal Article

Disease Risk Comorbidity Index for Patients Receiving Haploidentical Allogeneic Hematopoietic Transplantation

Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang

Journal Article